Sessions Planned

Translational Science 2013 Program

Wednesday, April 17, 2013

8:30-10:00 AM

Advocacy Training

This session will provide valuable information and training on effective communication with your legislators. Support research funding through participation!

10:00 AM - 3:00 PM

Hill Day Advocacy Visits

Following Advocacy Training, participants will head up to Capitol Hill to meet with their legislators. We will pair more experienced advocates with newer visitors. See your government at work and let your voice be heard!

7:30 AM - 12:30 PM

NIH Clinical Center Tour

Busing will be provided to the NIH Campus for a tour of the NIH Clinical Center. Space is limited, so sign up if you wish to see the NIH Campus and learn about the activities at the NIH Clinical Center.

1:00 - 4:00 PM

New! Grantsmanship Short Course

Dr. Robert Freishtat, a young investigator who has successfully transistioned from training (K) to research (R) grants, has developed an outstanding module for new investigators to learn about grant applications and writing. Space is limited for this hands-on workshop, especially appropriate for those seeking K trainee funding and those moving from K funding to research funding.

5:00 - 6:30 PM

Opening Reception

Join us as we welcome all attendees to the meeting. The reception is a terrific opportunity to meet old friends and colleagues, and to network. Besides, the food (hors d’oeuvres) and libation are outstanding!

Thursday, April 18, 2013

8:00 - 9:30 AM

Opening Plenary and Award Presentations

Welcome: Anantha Shekhar, MD, PhD, ACTS President
Introduction of AFMR President Abraham Thomas, MD MPH FACP and ACTS Executive Committee: Drs. Michael Lichtenstein, Rebecca Jackson, Roy Weiner, Ellie Schoenbaum, and Harry Selker
Three Award Presentations

Session chair: Roy Weiner
“The American Cancer Society's Extramural Grants Research Program”
Otis Brawley, MD, Scientific Director, American Cancer Society

The NIH is by far the largest funder of medical research in the U.S. Foundations can have a positive effect by plugging holes in the Federal research grants. For example, the American Cancer Society shifted its cancer research funding program to support the young investigators when the National Cancer Institute eliminated set aside funds for new investigators.

“The Evolving Role of Patients in the R&D Ecosystem”
Margaret Anderson, CEO, FasterCures

Lately it seems that drug developers and media alike are awakening to the profound impact of patients and patient organizations in driving the direction of medical research. Frustrated by the lack of options and armed with a unique understanding of the challenges, these foot-soldiers for cures are taking their fight from the bedside to the lab–funding high-risk, high-reward research projects, finding and fostering scientific expertise, and shifting the perception of patients as advocates to patients as participants. This presentation will address lessons in patient participation – how to find and engage them before you need their help, what they’re doing to speed medical progress in their diseases, and what you can learn from their pioneering efforts.

9:30 - 11:00 AM

Poster Session 1

Abstracts are accepted from trainees or more senior researchers on a variety of topics. Poster sessions offer not only the opportunity to present your work, but also to meet and network with leaders in your field.

11:30 AM - 1:00 PM

Joint lunchtime session with CR Forum—scientific presentations from the Clinical
Research Forum “Top 10” scientific awardees

Session Chair: Herbert Pardes, MD, Vice Chairman, Clinical Research Forum;
Executive Vice Chairman of the Board of Trustees, New York-Presbyterian Hospital

Introduce CR Forum Top 10 Clinical Research Achievement Awardees

Presentations of Achievements in Tetraplegia, Sickle Cell disease, whole-genome sequencing and neurodevelopment disorders, and aortic-valve replacement

1:00 - 2:30 PM

Concurrent Session 1

Two to Tango: Mentee and Mentor Evaluations
Organizer: Emma A. Meagher, MD and Jane EB Reusch, MD
With the ever increasing recognition of the importance of mentoring we recognize the parallel need for methods to evaluate the success and failures of our mentoring initiatives. This session will focus on practical ways to evaluate mentoring relationships. Both speakers will present their experience with the evaluation methods they have developed and implemented within their own institution.

Session Chair: Emma Meagher, MD, Associate Vice Provost for Research, University of Pennsylvania
Session Chair: Jane E.B. Reusch, MD, Professor, Medicine-Endocrinology, Metab and Diabetes, University of Colorado, Denver

Speakers

“Role of the Mentee in Mentoring Success: Enhancing and Evaluating Skill Building for Mentee and Mentor”
Anne Libby, PhD, Associate Professor, Department of Clinical Pharmacy, Pharmaceutical Outcomes Research, University of Colorado School of Pharmacy
"Challenges to Evaluating Mentoring Success"
Ellen Seely, MD, Professor of Medicine, Harvard Medical School, Vice Chair Faculty Development, Department of Medicine, Director of Clinical Research, Endocrinology, Diabetes and Hypertension Division, Brigham and Women's Hospital

Overcoming Challenges in Team Science

Organizers: Roy Weiner, MD and Ellie Schoenbaum, MD
This session will feature three clinical and translational team researchers. Each will tell his/her own story of team evolution, emphasizing the barriers and opportunities they encountered. Panelists will discuss effective communication between disciplines at different institutions collaborating on a multidisciplinary behavioral research project. There will be adequate time for Q&A.

Session Chair: Roy Weiner, MD, Associate Dean for Clinical Research Training, Edward G. Schlieder Chair in Medical Oncology, Tulane University School of Medicine
Session Chair: Ellie Schoenbaum, MD, Director of Medical Student Research at Einstein, Division Head, Division of Education , Department of Epidemiology & Population Health Director, Clinical Research Training Program, The Institute for Clinical and Translational Research

Speakers

Roee Holtzer PhD, Associate Professor of Psychology, Ferkauf Graduate School of Psychology and Department of Neurology, Albert Einstein College of Medicine at Yeshiva University.
Courtney Baker, PhD, Assistant Professor of Psychology at Tulane University
Madhu Mazumdar, PhD, MA, MS, Chief, Division of Biostatistics and Epidemiology, Department of Public Health, Professor of Biostatistics in Public Health

Partnering with Patient Groups on Drug Development

Organizer: Dan Ford, MD, MPH

Patient groups are increasing support and funding of targeted clinical trials. Come to this session to learn how this partnership can impact your research.

Session Chair: Daniel Ford, MD, MPH, Professor of Medicine, Vice Dean for Clinical Investigation, School of Medicine, Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University School of Medicine
Session Chair: Michael P. Boyle, MD, FCCP, Associate Professor of Medicine, Director, Johns Hopkins Adult Cystic Fibrosis Program

Speakers

Michael P. Boyle, MD, FCCP, Associate Professor of Medicine, Director, Johns Hopkins Adult Cystic Fibrosis Program
Ronald Bartek, President, Director and Co-founder, , Friedreich’s Ataxia Research Alliance
Preston W. Campbell, III, MD, Executive Vice-president for Medical Affairs, Cystic Fibrosis Foundation
Steven Rose, Ph.D., Chief Research Officer, Foundation Fighting Blindness

Pediatric Rare Diseases Growing Up: Outcomes in Adulthood

Organizer: Frederick Kaskel, MD, PhD, Albert Einstein College of Medicine
With medical advances achieved in the past few decades, children with rare congenital and chronic diseases are now surviving beyond childhood. Studies across the pediatric-adult transition are examining long term outcomes and have presented unique challenges in study design and implementation.

Session Chair: Frederick Kaskel, MD, PhD, Professor, Department of Pediatrics (Nephrology), Vice Chair for Affiliate and Network Relations, Department of Pediatrics Chief, Section of Nephrology, Department of Pediatrics, Albert Einstein College of Medicine

Speakers

“The Impact of Childhood Chronic Diseases on Peak Bone Mass and Life-long Bone Health”
Mary B. Leonard, MD, MSCE, Professor of Pediatrics and Epidemology, Director, Office of Clinical and Translational Research, The Children’s Hospital of Philadelphia Perelman School of Medicine at the University of Pennsylvania
“Clinical Trials in Children and Adults with Cystic Fibrosis”
Ronald Rubenstein, MD, PhD, Professor of Pediatrics Director, Cystic Fibrosis Center, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania
“N-carbamylglutamate: From Illegitimate Cofactor to Anti-Hyperammonemia Drug”
Mendel Tuchman, Children's National Medical Center, Scientific Director & Mary Elizabeth McGehee Joyce Professor for Genetics Research, Children's Research Institute Center for Genetic Medicine Research (CGMR) & Center for Clinical and Community Research (CCCR) George Washington University, School of Medicine and Health Sciences, Professor, Pediatrics & Biochemistry/Molecular Biology

Characteristics of MD, MD/PhD trainees Intending a Career in Translational Research

Organizer: Jennifer Kwan, Vice President, American Physician Scientist Association
Setting the backdrop for the session, pilot data representative of 5 institutions with both CTSAs and MSTPs from APSA’s Tomorrow's Physician initiative featuring characteristics of MD, MD/PhD predoctoral trainees intending a translational research career including specialty interests, current and anticipated obstacles, factors important to their career selection will be presented. In the second part of this session, a panel of CTSA PIs, heads will then discuss skillsets important for translational research, resources available to predoctoral trainees interested in translational research, ways trainees have gotten involved, and ways trainees are encouraged to participate in translational research.

Session Chair: Jennifer M Kwan, APSA Policy Chair and Vice President of External Affairs, University of Illinois Chicago MSTP
Session Chair: Barry Coller, MD, Physician in Chief, Vice President for Medical Affairs, Rockefeller University.

Speakers

Barry Coller, MD, Physician in Chief, Vice President for Medical Affairs, Rockefeller University.
Lars Berglund, MD, PhD, Senior Associate Dean for Research Director, UC Davis
Bradley Evanoff, MD, MPH, Assistant Dean for Clinical and Translational Research, Washington University
Doris Rubio PhD, Professor of Medicine, Biostatistics, Nursing, and Clinical and Translational Science University of Pittsburgh

2:45 - 4:45 PM

Mock Study Sections
These sessions include leaders from the NIH review community and a senior investigator, to demonstrate how grants are reviewed. This experience is highly valuable for the new or recent grant applicant. Each participant will review grants to learn how the process works. Space is limited, so sign up today!

3:00 - 4:30 PM

Concurrent Session 2

Integrating Biological Markers into Clinical Research Study Design

Organizer: Bradley Pollock, PhD
Over the last two decades, biologic markers—biomarkers—have been a cornerstone of biomedical research. Biomarkers can be used to identify populations at risk for a disease, disease characterization at the time of diagnosis, as measures to monitor treatment effects, and as prognostic markers. This session will consider the appropriate incorporation of biomarkers into the design of clinical and translational research studies, and their subsequent impact on clinical care and quality. Case examples and recommendations will be presented.

Session Chair: Brad H. Pollock, MPH, PhD, Professor and Chairman, Department of Epidemiology and Biostatistics, School of Medicine, Director, Biostatistics, Epidemiology Research Design Core, and Director, Biomedical Informatics Core, Institute for Integration of Medicine and Science, Clinical Translational Science Award, University of Texas Health Science Center at San Antonio

Speakers

Brad H. Pollock, MPH, PhD, Professor and Chairman, Department of Epidemiology and Biostatistics, School of Medicine, Director, Biostatistics, Epidemiology Research Design Core, and Director, Biomedical Informatics Core, Institute for Integration of Medicine and Science, Clinical Translational Science Award, University of Texas Health Science Center at San Antonio
Christopher J Lindsell, PhD, Professor and Vice Chair for Research, Department of Emergency Medicine, Co-Director of Biostatistics, Epidemiology and Research Design, Center for Clinical and Translational Science and Training, University of Cincinnati

Use of Electronic Medical Records for Research

Organizer: Kathryn Schuff, MD
This session will provide valuable and practical information of how to use electronic medical records (EMR) for research. Panelists include researchers who have utilized EMR data in a sophisticated manner, and will speak to strengths and caveats of this approach to answer research questions as well as insights into the infrastructure needed to take this approach.

Session Chair: Cynthia Morris, PhD, MPH, Vice Chair of Medical Informatics & Clinical Epidemiology, Professor of Medicine, Public Health & Preventative Medicine, Oregon Health & Science University.

Speakers

Shawn Murphy, MD, PhD, Associate Professor of Neurology, Massachusetts General Hospital
Charlie Bailey, MD, PhD, Attending Physician, Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Awardee Research (Joint with Clinical Research Forum)
This session will have three presentations from prize-winning researchers, emphasizing team science.

Scientific presentations from the Clinical Research Forum “Top 10” scientific awardees.

Session chair: Eugene Orringer, MD, Professor of Medicine, Director of Education for the University of North Carolina TraCS Institute, Director of the MD/PhD Program, University of North Carolina-Chapel Hill

Presentations by top awardees

5:00 - 6:30 PM

Awards and Joint plenary session with Clinical Research Forum
Session co-chairs: Dr. Anantha Shekhar, ACTS President, and Dr. Robert Califf, CR Forum Chairman
Presentation of 3 awards
Title TBD

Elias Zerhouni, M.D.

6:30 - 8:00 PM

Reception and Poster Session 2
Abstracts are accepted from trainees or more senior researchers on a variety of topics. Poster sessions offer not only the opportunity to present your work, but also to meet and network with leaders in your field.

Friday, April 19, 2013

8:00 - 9:00 AM

Plenary Session 3
“Reforming Research Ethics Regulations”
Ezekiel Emanuel, M.D., Ph.D., MPH

In the wake of the Affordable Care Act, research practices will undergo review and modification. Human subjects research, in particular, will be affected by the implementation of the revised health care bill. In this session, Dr. Emanuel will discuss his predictions regarding the future of clinical and translational science research and make recommendations for navigating the new policies and regulations.

9:00 - 10:30 AM

Poster Session 3
Abstracts are accepted from trainees or more senior researchers on a variety of topics. Poster sessions offer not only the opportunity to present your work, but also to meet and network with leaders in your field. Submit your abstract today!

10:30 AM - 12:00 PM

Concurrent Session 3

Meeting with NIH and PCORI Program Officers
Organizer: Nancy Desmond, PhD
After brief remarks from representatives of the NIH and PCORI, there will be opportunities for early-career investigators to meet with Program Officers from various NIH Institutes and with Program Area Directors from PCORI in small groups to discuss funding opportunities, potential applications, and application strategies.

Translational Research Collaborations with the Armed Services

Organizer: Michael Lichtenstein, MD, MSc/ Alan L. Peterson, PhD, ABPP
University of Texas Health Science Center at San Antonio
This session will discuss ways civilian academic researchers have successfully collaborated with the Department of Defense to conduct clinical translational research. Exemplars of database investigations, cross-sectional, and prospective clinical trials from the perspective of clinicians and researchers who conducted research while on active duty and continue to do collaborative studies with the military will be presented. Common challenges to conducting research with the DoD such as meeting regulatory requirements, staffing research studies, documentation of clinical workload, aligning with priorities of care, and execution of research funding will be considered.

Session Chair: Alan L. Peterson, PhD, ABPP, Professor, Department of Psychiatry, Chief, Division of Behavioral Medicine, Director, STRONG STAR Multidisciplinary PTSD Research Consortium
Deputy Chair for Military Collaboration, University of Texas Health Science Center at San Antonio

Speakers

Alan L. Peterson, PhD, ABPP, Professor, Department of Psychiatry, Chief, Division of Behavioral Medicine, Director, STRONG STAR Multidisciplinary PTSD Research Consortium
Deputy Chair for Military Collaboration, University of Texas Health Science Center at San Antonio
Stacey Young-McCaughan, RN, PhD, AOCN, Professor, Division of Behavioral Medicine, Consortium Coordinator, STRONG STAR, Program Manager, Cancer Therapy & Research Center (CTRC) Fitness Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio

Transdisciplinary Research Collaborations: Challenges, Benefits and Needed Competencies

Organizer: Kara L. Hall, PhD, National Cancer Institute
The speakers will draw on a wide array of sources, including in-depth interviews with researchers and first-hand experience, to illuminate the challenges, benefits, and competencies needed to be successful in engaging and leading transdiscplinary team-based science. The speakers will share lessons learned from several transdisciplinary research initiatives, showcase key findings from the emerging field of the science of team science, and highlight critical facilitators to conducting integrative translational science with collaborators across disciplines, fields, and professions.

Session Chair and Speaker:
“Lessons Learned from Transdisciplinary Researchers and Findings from the Science of Team Science Field”
Kara L. Hall, PhD, Director, Science of Team Science (SciTS) Team, Co-Director, Theories Project Health Scientist, Science of Research and Technology Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute
Session Chair and Speaker:
“Challenges and Benefits of Current Transdisciplinary Initiatives”
Sarah Gehlert, PhD, E. Desmond Lee Professor of Racial and Ethnic Diversity, The George Warren Brown School of Social Work, Professor, Department of Surgery, Washington University

Powerful Teams: Capitalizing on Diversity
Organizer: Jasjit S Ahluwalia, MD, MPH, MS
Leaders, usually unconsciously, will populate their teams with members who think like they do. In addition, they may also engage and are most comfortable with members who resemble them, with regards to race/ethnicity, gender, and other attributes, such as religion, attendance at elite colleges, etc. Increasingly, evidence points to greater success for diverse teams. This workshop will focus on the first two attributes, but also talk broadly about building powerful teams. The session chair has experience as a department chair, associate dean, and center director, and serves on a number of boards and a NIH advisory council. The co-chair was the first woman to have served as a medical school dean at two institutions, was the Chair of the AAMC, and has served on numerous national panels.

Session Chair: Jasjit S Ahluwalia, MD, MPH, MS, Executive Director, Center for Health Equity, Associate Director, Clinical and Translational Sciences Institute (CTSI) and Director, Research Education, Training and Career Development, University of Minnesota Medical School

Speakers

Jasjit S Ahluwalia, MD, MPH, MS, Executive Director, Center for Health Equity, Associate Director, Clinicnanal and Translational Sciences Institute (CTSI) and Director, Research Education, Training and Career Development, University of Minnesota Medical School
Deborah E. Powell, MD, Dean Emeritus, University of Minnesota School of Medicine

Navigating the FDA Regulatory Landscape

Organizers: Kathryn Schuff, MD, and Emma Meagher, MD
This session will focus on practical ways to navigate the landscape of FDA regulated research with a focus on IND regulation. The perspective of an IND sponsor junior investigator, a regulatory support specialist working in an academic setting and an FDA officer will participate in sharing their experiences and practice pearls for successful conduct of FDA complaint research.

Session Chair: Emma Meagher, MD, Associate Vice Provost for Research University of Pennsylvania

Speakers

“Sponsoring and IND? Ignorance is Not Always Blissful”
Lisa A. Speicher, PhD, Director, Clinical Trials Office, The Childrens Hospital of Philadelphia“
"Navigating the Path to a Successful Investigational New Drug (IND) Application: Perspectives of an IND Sponsor”
Marion Vetter, MD, MTR, Instructor, Department of Medicine, University of Pennsylvania
Larissa Lapteva, MD, MHS, Medical Officer, Food and Drug Administration

12:00 - 1:00 PM

Closing Plenary - NCATS: Catalyzing Translational Innovation
Dr. Abraham Thomas, Chair

Christopher Austin, M.D., Director of the National Center for Advancing Translational Science (NCATS).

Meeting adjourned

*Translational Science 2013 acknowledges the support of Grant R13TR000037, “Clinical Research Scholars and Educators Training 2012-2014,” from the National Center for Advancing Translational Sciences, National Institutes of Health, Department of Health and Human Services